瘦素(Leptin)是由ob基因編碼、在脂肪組織中生成的一種脂肪代謝調(diào)控產(chǎn)物，在代謝和調(diào)控體重等方面發(fā)揮重要作用。它通過下丘腦中的瘦素受體發(fā)出信號，降低食欲，增加能量消耗。在外周組織中，瘦素能拮抗胰島素信號傳導(dǎo)，增加脂肪酸氧化，減少胰島β細(xì)胞的胰島素分泌，并促進(jìn)生育。它在脂肪細(xì)胞中的表達(dá)可以被其他脂肪因子如IL-6（刺激）和TNF-α（抑制）以旁分泌方式調(diào)節(jié)。瘦素缺乏的小鼠表現(xiàn)出嚴(yán)重的胰島素抵抗、肥胖和生育能力下降，所有這些都可以通過外源性瘦素給藥而逆轉(zhuǎn)。還有研究表明，瘦素與心血管疾病有關(guān)，因?yàn)樗閷?dǎo)了許多促炎和促動脈粥樣硬化作用，如內(nèi)皮素-1（ET-1）表達(dá)增加、活性氧（ROS）積累、單核細(xì)胞趨化蛋白-1（MCP-1）分泌以及交感血管張力和血壓增加。

● 靈活：適用于正常和病理樣本

● 高靈敏：可檢測<26 pg/ml的小鼠瘦素水平

● 快速：僅需3小時就可獲得39個樣本的重復(fù)結(jié)果

● 方便：預(yù)包被板和即用型試劑為您節(jié)省實(shí)驗(yàn)時間

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部分產(chǎn)品引用文獻(xiàn)

1. High salt diet does not impact the development of acute myeloid leukemia in mice: M. Janakiraman, et al.; Cancer Immunol. Immunother. 72, 265 (2023)

2. eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress: L. Morató, et al.; Sci. Adv. 8, eabj9109 (2022) 

3. Transcription factor CREB3 is a potent regulator of high-fat diet-induced obesity and energy metabolism: B.S. Smith, et al.; Int. J. Obes. 46, 1446 (2022)

4. The effects of mirabegron on obesity-induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue: C. Peres Valgas da Silva, et al.; Clin. Exp. Pharmacol. Physiol. 48, 1477 (2021)

5. Anti-Obesity Effects of Collagen Peptide Derived from Skate (Raja kenojei) Skin Through Regulation of Lipid Metabolism: M. Woo, et al.; Mar. Drugs 16, 306 (2018) 

6. Anti-obesity effects of pectinase and cellulase enzyme?treated Ecklonia cava extract in high?fat diet?fed C57BL/6N mice: I.H. Kim, et al.; Int. J. Mol. Med. 41, 924 (2018), Application(s): ELISA using mouse serum 

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