BioXcell熱銷產品InVivoMab anti-mouse CD28/小鼠CD28單克隆抗體
產品描述：
The 37.51 monoclonal antibody reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells. CD28 is a receptor for CD80 (B7-1) and CD86 (B7-2). Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells. The 37.51 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells and provide a costimulatory signal for CTL induction.
BioXcell InVivoMab anti-mouse CD28 37.51單克隆抗體與小鼠CD28反應，CD28是一種45kDa的共刺激受體，也是Ig超家族的一員。CD28由胸腺細胞，大多數外周T細胞和NK細胞表達。CD28是CD80（B7-1）和CD86（B7-2）的受體。通過CD28的信號傳導增強了IL-2和IL-2受體的表達以及CD3活化的T細胞的細胞毒性。37.51抗體已被證明能刺激活化的T細胞和NK細胞的增殖和細胞因子的產生，并為CTL誘導提供共刺激信號。
產品詳情：
產品名稱 | InVivoMAb anti-mouse CD28 |
產品貨號 | BE0015-1 |
產品規格 | 1/5/25/50/100mg |
反應種屬 | Mouse |
克隆號 | 37.51 |
同種型 | Syrian Hamster IgG2 |
免疫原 | C57BL/6 mouse T cell lymphoma EL-4 cells |
實驗應用 | in vitro T cell stimulation/activation in vivo CD28 blockade |
產品形式 | PBS, pH 6.0 0.01% Tween,Contains no stabilizers or preservatives |
純度 | >95%, Determined by SDS-PAGE |
無菌處理 | 0.2 µm filtration |
純化方式 | Protein G |
RRID | AB_1107624 |
分子量 | 150 kDa |
保存條件 | 抗體原液保存在4°C，不能冷凍保存。 |
推薦同型對照 | InVivoMAb polyclonal Syrian hamster IgG（貨號BE0087） |
推薦抗體稀釋液 | InVivoPure pH 6.0T Dilution Buffer（貨號IPT060） |
該產品自上市已被多篇SCI文獻引用，品質有保證，以下是部分已發表的文獻引用：
應用 | 文章 |
體外T細胞刺激/激活 (in vitro T cell stimulation/activation) | 1. Lacher, S. M., et al. (2018). 'NF-kappaB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling' J Autoimmun 94: 110-121. 2. Wendland, K., et al. (2018). 'Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis' J Immunol 201(2): 524-532. 3. Ron-Harel, N., et al. (2016). 'Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation' Cell Metab 24(1): 104-117. 4. Gu, A. D., et al. (2015). 'A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor beta receptor signaling' Immunity 42(1): 68-79. 5. Choi, Y. S., et al. (2015). 'LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6' Nat Immunol 16(9): 980-990. |
體內CD28阻斷 (in vivo CD28 blockade) | 1. Rouhani, S. J., et al. (2015). 'Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction' Nat Commun 6: 6771. 2. Eberlein, J., et al. (2012). 'Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity' J Virol 86(4): 1955-1970. |
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